| |
Control
|
DM CVD-
|
|---|
|
n
|
18
|
22
|
|
Age (yrs)
|
51.7 (8)
|
56.0 (8) *
|
|
Male : Female
|
14:4
|
16:6
|
|
Diabetes duration (yrs)
|
N/A
|
6.5 (5.9)
|
|
BMI (kg/m2)
|
26.6 (6.0)
|
27.4 (7.2)
|
|
HbA1c (%)
|
5.1 (0.4)
|
7.0 (1.4) **
|
|
Fasting plasma glucose (mmol/l)
|
4.7 (0.7)
|
8.6 (2.9) **
|
|
Treatment
| | |
|
Aspirin
|
0
|
0
|
|
Statin
|
0
|
0
|
|
Diet alone
|
-
|
6
|
|
Sulphonylurea alone
|
-
|
8
|
|
Metformin alone
|
-
|
3
|
|
Combination
|
-
|
5
|
|
MMP-1 (ng/ml)
|
5.5 (5)
|
6.4 (5.9)
|
|
MMP-3 (ng/ml)
|
0.0 (1.2)
|
0.0 (0.8)
|
|
MMP-9 (ng/ml)
|
42.1 (82)
|
48.2 (51)
|
|
TIMP-1 (ng/ml)
|
192.9 (108)
|
163.0 (111)
|
- * p < 0.05 compared to controls ** p < 0.0001 compared to controls. Clinical data shown as mean (SD), MMP and TIMP-1 data shown as median (IQR)
