|
A
|
Amylin (hyperamylinemia)/amyloid toxicity
|
ROS
|
| |
Ang II (also induces PKC)
|
ROS
|
| |
AGEs/AFEs (advanced Glycosylation / fructosylation products)
|
ROS
|
| |
Antioxidant reserve compromised
|
ROS
|
| |
Absence of antioxidant network
|
ROS
|
| |
Ageing
|
ROS
|
| |
Angiogenesis (induced redox stress) Arteriogenesis (impaired PAI-1)
|
ROS
|
| |
Atherosclerosis – Atheroscleropathy. [ROS beget ROS ]
|
ROS
|
|
F
|
Free fatty acid toxicity
|
ROS
|
|
L
|
Lipotoxicity
|
ROS
|
|
I
|
Insulin toxicity (hyperinsulinemia-hyperproinsulinemia) (endogenous)
|
ROS
|
| |
Inflammation toxicity
|
ROS
|
|
G
|
Glucotoxicity (compounds peripheral insulin resistance) reductive stress
|
ROS plus
|
| |
Sorbitol / 'olyol pathway
|
PKC
|
| |
Pseudohypoxia (NADH/NAD increased)
| |
|
H
|
Hypertension toxicity
|
ROS
|
| |
t homocysteine toxicity
|
ROS
|
|
T
|
Triglyceride toxicity
|
ROS
|
