Advertisement
Table 5 eNOS reaction the three critical arms
|
| IF THE eNOS REACTION IS UNCOUPLED: THEN THE REACTION IS: |
|
| (L-arginine is not converted to NO and L-citrulline). |
| TREATMENT PARADIGM: |
| (1) Prevent competitive inhibition by ADMA (Reduce substrates: LDL-C, Triglycerides, Homocysteine, and Glucotoxicity formation. Prevent L-arginine from being converted to nitroarginine by nitrosylation. Reducing Redox Stress – A-FLIGHT toxicities reduction of ROS. ARGININE SUPPLEMENTATION. |
| (2) Prevent hs-CRP from decreasing eNOS by lowering hs-CRP and preventing glycation of Enos enzyme. Aggressive treatment of elevated substrates. |
| (3) Add FOLIC ACID not only to lower Hcy and ADMA levels but also to restore BH2, BH3 to the active catalytic cofactor BH4. Use the RAAS acronym and prevent the A-FLIGHT Toxicities (ROS) from developing i.e. decrease the manifold toxicities of MS, IR, PD and overt T2DM. |
| BE AGGRESSIVE AND TREAT TO KNOWN GOALS: |
