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IF THE eNOS REACTION IS UNCOUPLED: THEN THE REACTION IS:
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(L-arginine is not converted to NO and L-citrulline).
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TREATMENT PARADIGM:
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(1) Prevent competitive inhibition by ADMA (Reduce substrates: LDL-C, Triglycerides, Homocysteine, and Glucotoxicity formation. Prevent L-arginine from being converted to nitroarginine by nitrosylation. Reducing Redox Stress – A-FLIGHT toxicities reduction of ROS. ARGININE SUPPLEMENTATION.
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(2) Prevent hs-CRP from decreasing eNOS by lowering hs-CRP and preventing glycation of Enos enzyme. Aggressive treatment of elevated substrates.
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(3) Add FOLIC ACID not only to lower Hcy and ADMA levels but also to restore BH2, BH3 to the active catalytic cofactor BH4. Use the RAAS acronym and prevent the A-FLIGHT Toxicities (ROS) from developing i.e. decrease the manifold toxicities of MS, IR, PD and overt T2DM.
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BE AGGRESSIVE AND TREAT TO KNOWN GOALS:
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