|
GOOD
|
BAD
|
|---|
|
eNO, nNO
|
iNO *
|
|
Chromosomes 7,12
|
Chromosome 17
|
|
Duration: Seconds to minutes
|
Duration: Hours to days
|
|
Signaling molecule.
|
Killer molecule.
|
|
Regulated: small bursts
|
Unregulated: larger bursts and longer duration
|
|
Cytoprotective
|
Cytotoxic
|
- *In host defense mechanisms iNO does just what we want it to, i.e. it kills invading organisms. Inducible NO can also be thought of as inflammatory NO. Paradoxically, in both acute and chronic inflammatory states iNO also kills the native hosts cells in the immediate surrounding area.
