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Table 2 Odds ratios for hypertension in relation to the α2B-adrenoceptor genotype and other cardiovascular risk factors.

From: The insertion/deletion variation in the α2B-adrenoceptor does not seem to modify the risk for acute myocardial infarction, but may modify the risk for hypertension in sib-pairs from families with type 2 diabetes

N (hypertensives) AMI 143 (127) No AMI 144 (101)
  OR (95% CI) P OR (95% CI) P
Univariate models     
   α2B-AR D vs. I 1.6 (0.6–4.7) 0.36 1.8 (0.9–3.7) 0.12
   α2B-AR ID vs. II 1.4 (0.4–4.1) 0.59 1.3 (0.6–2.8) 0.53
   α2B-AR DD vs. II 2.6 (0.5–13.2) 0.26 3.7 (1.2–11.1) 0.021
   α2B-AR DD vs. II + ID 2.2 (0.5–10) 0.36 3.2 (1.2–8.9) 0.026
   Age 1.0 (0.9–1.0) 0.79 1.1 (1.0–1.1) 0.008
   BMI 1.1 (1.0–1.4) 0.037 1.1 (1.0–1.2) 0.038
   LDL cholesterol 1.3 (1.0–1.8) 0.059 1.5 (1.0–2.2) 0.032
   Smoking 0.6 (0.2–2.0) 0.43 0.5 (0.2–1.2) 0.11
   Diabetes 1.9 (0.6–5.8) 0.29 1.3 (0.6–2.7) 0.48
Multivariate model*     
   α2B-AR DD vs. II + ID N/A   4.0 (1.2–13.3) 0.024
   Age N/A   1.1 (1.0–1.1) 0.020
   BMI N/A   1.2 (1.0–1.4) 0.006
   LDL cholesterol N/A   1.8 (1.1–3.0) 0.032
  1. Results are from univariate and conditional multivariate logistic regression models. *Data are presented for the last step of the stepwise conditional insertion of variables into the models. Adjustment was done for age, sex, smoking, diabetes, BMI, and LDL cholesterol, which were inserted into a multivariate logistic regression model in a stepwise manner (p = 0.05 for entry and 0.1 for removal). N/A denotes not applicable (all the variables were rejected by the models). I, insertion; D, deletion; BMI, body mass index