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Figure 7 | Cardiovascular Diabetology

Figure 7

From: Caffeic acid phenethyl amide ameliorates ischemia/reperfusion injury and cardiac dysfunction in streptozotocin-induced diabetic rats

Figure 7

Effects of CAPA treatment on infarct size in diabetic rats. After I/R injury, area at risk (A) and infarct size/area at risk ratio (B) in diabetic rats were calculated. For chronic treatments, the animals were divided into three groups: control, age- and sex-matched normal rats, n = 16; STZ-vehicle, age- and sex-matched diabetic animals administered distilled water orally for 4 weeks starting 4 weeks after STZ induction, n = 13; and STZ-CAPA, CAPA 1 mg/kg administered orally once daily for 4 weeks starting 4 weeks after STZ induction, n = 6. Data are expressed as mean ± SEM. *P < 0.05 compared with control group and #P < 0.05 compared with STZ-vehicle group. BS 0, basal value just before ischemia; IS 45, 45 min after ischemia but just before reperfusion; RP 60, 60 min after reperfusion; RP 120, 120 min after reperfusion.

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Cardiovascular Diabetology

ISSN: 1475-2840