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Figure 6 | Cardiovascular Diabetology

Figure 6

From: Caffeic acid phenethyl amide ameliorates ischemia/reperfusion injury and cardiac dysfunction in streptozotocin-induced diabetic rats

Figure 6

Effects of CAPA treatment on heart rate and mean blood pressure in diabetic rats. The heart rate (A) and mean blood pressure (B) during the I/R period in control and diabetic rats were recorded. For chronic treatments, the animals were divided into three groups: control, age- and sex-matched normal rats, n = 16; STZ-vehicle, age- and sex-matched diabetic animals administered distilled water orally for 4 weeks starting 4 weeks after STZ induction, n = 13; and STZ-CAPA, CAPA 1 mg/kg administered orally once daily for 4 weeks starting 4 weeks after STZ induction, n = 6. BS 0, basal value just before ischemia; IS 45, 45 min after ischemia but just before reperfusion; RP 60, 60 min after reperfusion; RP 120, 120 min after reperfusion. Data are expressed as mean ± SEM. *P < 0.05 compared with control group and #P < 0.05 compared with STZ-vehicle group.

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