Figure 2

Ischemia/reperfusion model and chronic treatment time course in type 1 diabetic rats. All animals underwent coronary artery occlusion for 45 min followed by 2 hours of reperfusion. CAPA (3 and 15 mg/kg) and dmCAPA (15 mg/kg) were administered intraperitoneally 30 min before reperfusion while the NOS inhibitor (l- NAME; 3 mg/kg, intraperitoneal) was given before LAD occlusion (panel 1). For chronic treatment, type 1 diabetes was induced by STZ over 4 weeks in 8-week-old rats that were then treated with vehicle or CAPA for 4 weeks (panel 2).