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Figure 6 | Cardiovascular Diabetology

Figure 6

From: Dopamine D4 receptors inhibit proliferation and migration of vascular smooth muscle cells induced by insulin via down-regulation of insulin receptor expression

Figure 6

Effects of PD168077 on the proliferation and apoptosis of balloon-injured carotid in SD rats with hyperinsulinemia. Carotid balloon-injured rats were intraperitoneally injected with vehicle or PD168077 (6 mg/kg/day) for 14 days. Proliferation was measured by immunoblotting of proliferating cell nuclear antigen (PCNA) (A) and cleaved caspase 3 expression (B) in PD168077-treated and control rats. Results are expressed as the ratio of PCNA to Histone H3 densities or ratio of caspase-3 to α-actin densities (n = 4, *P < 0.05 vs. control).

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Cardiovascular Diabetology

ISSN: 1475-2840