Figure 1

Model-adjusted change from baseline in haematological and biochemistry parameters, by time point. A). White blood cell counts (total) (10⁹/L). B). Absolute neutrophil counts (10⁹/L). C). Platelet count (direct) (10⁹/L). D). Haemoglobin (g/L). E). Serum glutamic pyruvic transaminase/ALT (U/L). F). Serum glutamic oxaloacetic transaminase/AST (U/L). G). Bilirubin (total) (μmol/L). H). Cholesterol (total) (mmol/L). Low dose: 0.03 mg/kg i.v. once; intermediate dose: 0.1 and 0.3 mg/kg i.v. once, 5 and 15 mg s.c. monthly; medium dose: 1.5 mg/kg i.v. once, 50 mg s.c. monthly and 150 mg s.c. once; high dose: 10 mg/kg i.v. once and 150 mg s.c. monthly.