Figure 4

Effects of Saxagliptin on clonogenesis and proliferation. A) Representative microphotographs of PACs culture from type 2 diabetic patients and healthy controls exposed to Saxagliptin with or without SDF-1α supplementation. B) Analysis of cell cycle phases in cultured PACs of healthy subjects (left) and type 2 diabetic patients (right). *p < 0.05 versus the unstimulated control condition (Ctrl). C) Representative microphotographs of murine hematopoietic colonies exposed to Saxagliptin with or without SDF-1α supplementation. D) Quantification of total (left) and types (right) of hematopoietic colonies in relation to treatment with Saxagliptin, with or without SDF-1α supplementation. *p < 0.05 versus the unstimulated control condition (Ctrl).