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Table 4 Association of mortality with HbA 1c and platelet morphology in non-diabetic participants according to PLA1A2 polymorphism

From: PLA1A2 platelet polymorphism predicts mortality in prediabetic subjects of the population based KORA S4-Cohort

 

HbA1c≤5.5%

5.5% < HbA1c< 6.5%

 

(HbA1c≤37 mmol/mol)

(37 mmol/mol < HbA1c< 48 mmol/mol)

A1A1(N = 1,597)

 

AxA2(N = 595)

 

A1A1(N = 1,167)

 

AxA2(N = 460)

 

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

HbA1c

0.81 (0.23, 2.82)

0.74

0.52 (0.08, 3.31)

0.49

1.49 (0.50, 4.49)

0.48

7.85 (1.66, 37.14)

0.009

Platelet count

1.04 (1.00, 1.07)

0.03

1.02 (0.94, 1.10)

0.69

0.98 (0.95, 1.02)

0.35

1.01 (0.95, 1.08)

0.65

Platelet mass

0.996 (0.992, 0.999)

0.03

1.00 (0.94, 1.10)

0.66

1.00 (0.997, 1.005)

0.60

1.00 (0.991, 1.004)

0.52

MPV

2.46 (1.07, 5.61)

0.03

1.34 (0.18, 9.81)

0.77

0.78 (0.33, 1.85)

0.58

1.85 (0.44, 7.76)

0.40

  1. The estimate indicates the hazard ratio (HR) with 95% confidence interval (CI) for every unit increase of the variable. The model was adjusted for age, sex, waist-hip ratio, blood pressure (diastolic and systolic), cholesterol (total, HDL, LDL), smoking status (categorized: non-smoker, former smoker, current smoker), alcohol intake (categorized: ≥20 g/day for women; ≥40 g/day for men), physical activity (categorized: >1 h per week).
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Cardiovascular Diabetology

ISSN: 1475-2840