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Table 2 HbA 1c level and platelet morphology in the participants according to diabetic state and PLA1A2 polymorphism

From: PLA1A2 platelet polymorphism predicts mortality in prediabetic subjects of the population based KORA S4-Cohort

 

Values

Logistic regression

 

All (N = 4,028)

A1A1 (mean ± SD)

AxA2 (mean ± SD)

Odds ratio (95% CI)

P  

HbA1c [%]

5.56 ± 0.58

5.60 ± 0.71

1.03 (0.96, 1.11)

0.42

HbA1c [mmol/mol]

37.3 ± 6.3

37.7 ± 7.8

  

MPV [fl]

8.76 ± 0.96

8.66 ± 0.89

0.90 (0.83, 0.96)

0.003

Platelet mass

2,100 · 2 ± 454.4

2,090.4 ± 460.8

0.99 (0.92, 1.07)

0.75

Platelet count [nl]

242.7 ± 58.3

243.9 ± 57.4

1.03 (0.96, 1.12)

0.33

Diabetes (N = 209)

    

HbA1c [%]

7.04 ± 1.41

7.63 ± 1.64

1.19 (1.04, 1.35)

0.01

HbA1c [mmol/mol]

53.4 ± 15.4

68.9 ± 8.9

  

MPV [fl]

9.02 ± 1.07

8.97 ± 0.96

1.03 (0.76, 1.38)

0.86

Platelet mass

1,996.80 ± 516.49

1,979.13 ± 420.85

0.93 (0.67, 1.30)

0.70

Platelet count [nl]

224.97 ± 65.86

223.20 ± 52.06

0.91 (0.66, 1.25)

0.57

Non-Diabetes (N = 3,819)

    

HbA1c [%]

5.48 ± 0.35

5.48 ± 0.36

0.97 (0.85, 1.11)

0.69

HbA1c [mmol/mol]

36.4 ± 3.8

36.4 ± 3.9

  

MPV [fl]

8.74 ± 0.95

8.64 ± 0.89

0.89 (0.83, 0.96)

0.002

Platelet mass

2,105.76 ± 450.22

2,096.83 ± 462.37

0.99 (0.91, 1.07)

0.85

Platelet count [nl]

243.61 ± 57.72

245.11 ± 57.46

1.04 (0.97, 1.12)

0.26

  1. The estimates are shown as the adjusted odds ratio with 95% confidence interval (CI) for every unit increase of HbA1c. Model was adjusted for age, sex, waist-hip ratio, blood pressure (diastolic and systolic), cholesterol (total, HDL, LDL), smoking status (categorized: non-smoker, former smoker, current smoker), alcohol intake categorized: ≥20 g/day for women; ≥40 g/day for men), physical activity (categorized: >1 h per week).
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Cardiovascular Diabetology

ISSN: 1475-2840