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Table 3 Baseline characteristics as a function of the median plasma dp-ucMGP level

From: Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein

 

All

[dp-ucMGP] ≤ 559.5 pM

[dp-ucMGP] > 559.5 pM

p

 

n = 198

n = 99

n = 99

 

Age (years)

64 ± 8

63 ± 9

66 ± 8

0.002

Diabetes duration (years)

15 ± 10

14 ± 10

15 ± 9

0.358

Male gender n (%)

158 (80)

82 (83)

76 (77)

0.288

Body mass index (kg/m 2 )

29 ± 5

28 ± 5

30 ± 5

<0.0001

SBP (mmHg)

127 ± 17

126 ± 17

128 ± 17

0.377

DBP (mmHg)

73 ± 9

73 ± 9

72 ± 8

0.487

Smoking habit n (%)

119 (60)

58 (59)

61 (62)

0.663

Previous CVD n (%)

139 (70)

66 (67)

73 (74)

0.277

Glycaemia (mmol/l)

8.2 ± 2.8

8.0 ± 2.6

8.3 ± 2.9

0.401

(7.8)

(7.6)

(8.0)

 

HbA1c (%)

7.8 ± 1.5 (7.5)

7.7 ± 1.4

7.9 ± 1.5

0.572

 

(7.5)

(7.5)

 

GFR MDRD (mmol/l)

80 ± 19

82 ± 19

70 ± 19

<0.0001

Microalbuminuria (mg/l)

166 ± 840

169 ± 1132

162 ± 373

<0.0001

(23)

(14)

(33)

 

Calcium (mmol/l)

2.30 ± 0.10

2.30 ± 0.10

2.34 ± 0.10

0.055

Phosphate (mmol/l)

1.02 ± 0.15

1.04 ± 0.20

1.00 ± 0.20

0.164

Intact PTH

54.5 ± 27.5

50.8 ± 26.0

58.5 ± 28.9

0.030

(pg/mL)

(46.9)

(45.2)

(52.0)

 

25(OH)Vit D (ng/ml)

13.8 ± 8.4

14.4 ± 8.2

13.2 ± 8.5

0.175

(12.0)

(13.0)

(11.0)

 

CRP

2.2 ± 1.5

2.2 ± 2.6

2.2 ± 2.5

0.725

(mg/l)

(1.2)

(1.3)

(1.1)

 

Triglycerides

1.6 ± 1.1

1.4 ± 1.1

1.6 ± 0.9

0.039

(mmol/L)

(1.3)

(1.2)

(1.4)

 

Total cholesterol (mmol/l)

3.7 ± 0.9

3.7 ± 0.8

3.8 ± 0.9

0.283

LDL cholesterol

1.9 ± 0.7

1.9 ± 0.7

2.0 ± 0.8

0.403

(mmol/L)

(1.8)

(1.8)

(1.8)

 

Total cholesterol/HDL

3.7 ± 1.6

3.5 ± 1.1

3.9 ± 1.8

0.053

cholesterol

(3.5)

(3.3)

(3.5)

 

Peripheral calcification score

2528 ± 5779

1609 ± 3983

3447 ± 7040

<0.0001

(524)

(274)

(1096)

 

t-ucMGP (nM)

4868 ± 1613

4815 ± 1689

4921 ± 1539 (4787)

0.460

(4741)

(4616)

  

dp-ucMGP (pM)

627 ± 451

342 ± 142

912 ± 474

NA

 

(559)

(352)

(755)

 

VKA treatment n (%)

6 (3)

0 (0)

6 (6)

0.013

  1. Data are given as means ± SD for normally distributed measures with addition of (median) for non-normally distributed values for variables with a non-Gaussian distribution or as the number (percentage) for binary variables.
  2. SBP: systolic blood pressure; DBP: diastolic blood pressure; CVD: cardiovascular disease; HbA1c: haemoglobin A1C; GFR MDRD: Glomerular filtration rate calculated with the Modification of Diet in Renal Disease formula; PTH: parathyroid hormone; CRP: C-reactive protein, t-ucMGP: total uncarboxylated matrix Gla-protein; dp-ucMGP: dephospho-uncarboxylated matrix Gla-protein. VKA: vitamin K antagonist.