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Table 3 Baseline characteristics as a function of the median plasma dp-ucMGP level

From: Vascular calcification in patients with type 2 diabetes: the involvement of matrix Gla protein

  All [dp-ucMGP] ≤ 559.5 pM [dp-ucMGP] > 559.5 pM p
  n = 198 n = 99 n = 99  
Age (years) 64 ± 8 63 ± 9 66 ± 8 0.002
Diabetes duration (years) 15 ± 10 14 ± 10 15 ± 9 0.358
Male gender n (%) 158 (80) 82 (83) 76 (77) 0.288
Body mass index (kg/m 2 ) 29 ± 5 28 ± 5 30 ± 5 <0.0001
SBP (mmHg) 127 ± 17 126 ± 17 128 ± 17 0.377
DBP (mmHg) 73 ± 9 73 ± 9 72 ± 8 0.487
Smoking habit n (%) 119 (60) 58 (59) 61 (62) 0.663
Previous CVD n (%) 139 (70) 66 (67) 73 (74) 0.277
Glycaemia (mmol/l) 8.2 ± 2.8 8.0 ± 2.6 8.3 ± 2.9 0.401
(7.8) (7.6) (8.0)  
HbA1c (%) 7.8 ± 1.5 (7.5) 7.7 ± 1.4 7.9 ± 1.5 0.572
  (7.5) (7.5)  
GFR MDRD (mmol/l) 80 ± 19 82 ± 19 70 ± 19 <0.0001
Microalbuminuria (mg/l) 166 ± 840 169 ± 1132 162 ± 373 <0.0001
(23) (14) (33)  
Calcium (mmol/l) 2.30 ± 0.10 2.30 ± 0.10 2.34 ± 0.10 0.055
Phosphate (mmol/l) 1.02 ± 0.15 1.04 ± 0.20 1.00 ± 0.20 0.164
Intact PTH 54.5 ± 27.5 50.8 ± 26.0 58.5 ± 28.9 0.030
(pg/mL) (46.9) (45.2) (52.0)  
25(OH)Vit D (ng/ml) 13.8 ± 8.4 14.4 ± 8.2 13.2 ± 8.5 0.175
(12.0) (13.0) (11.0)  
CRP 2.2 ± 1.5 2.2 ± 2.6 2.2 ± 2.5 0.725
(mg/l) (1.2) (1.3) (1.1)  
Triglycerides 1.6 ± 1.1 1.4 ± 1.1 1.6 ± 0.9 0.039
(mmol/L) (1.3) (1.2) (1.4)  
Total cholesterol (mmol/l) 3.7 ± 0.9 3.7 ± 0.8 3.8 ± 0.9 0.283
LDL cholesterol 1.9 ± 0.7 1.9 ± 0.7 2.0 ± 0.8 0.403
(mmol/L) (1.8) (1.8) (1.8)  
Total cholesterol/HDL 3.7 ± 1.6 3.5 ± 1.1 3.9 ± 1.8 0.053
cholesterol (3.5) (3.3) (3.5)  
Peripheral calcification score 2528 ± 5779 1609 ± 3983 3447 ± 7040 <0.0001
(524) (274) (1096)  
t-ucMGP (nM) 4868 ± 1613 4815 ± 1689 4921 ± 1539 (4787) 0.460
(4741) (4616)   
dp-ucMGP (pM) 627 ± 451 342 ± 142 912 ± 474 NA
  (559) (352) (755)  
VKA treatment n (%) 6 (3) 0 (0) 6 (6) 0.013
  1. Data are given as means ± SD for normally distributed measures with addition of (median) for non-normally distributed values for variables with a non-Gaussian distribution or as the number (percentage) for binary variables.
  2. SBP: systolic blood pressure; DBP: diastolic blood pressure; CVD: cardiovascular disease; HbA1c: haemoglobin A1C; GFR MDRD: Glomerular filtration rate calculated with the Modification of Diet in Renal Disease formula; PTH: parathyroid hormone; CRP: C-reactive protein, t-ucMGP: total uncarboxylated matrix Gla-protein; dp-ucMGP: dephospho-uncarboxylated matrix Gla-protein. VKA: vitamin K antagonist.