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Figure 4 | Cardiovascular Diabetology

Figure 4

From: The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus

Figure 4

S1P reconstituted on HDL repair the function of glycated HDL in a dose dependent manner. A-B: S1P binding on HDL can enhance the COX-2 expression (A) and S1P restores the glycated HDL loss of function in inducing COX-2 expression (B) at 0.1 μM, 1 μM and 5 μM concentration of S1P (binding with 30 μg/ml HDL or glycated HDL). Each experiment was repeated three times.

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Cardiovascular Diabetology

ISSN: 1475-2840