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Figure 2 | Cardiovascular Diabetology

Figure 2

From: The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus

Figure 2

Levels of S1P and its related enzymes were detected by UPLC-MS/MS and real-time PCR. Levels of HDL-bound S1P were significantly increased in diabetes mellitus than control subjects. A-B: S1P level was normalized by HDL-c in plasma between control subjects and T2DM (A), levels of diabetic HDL3- associated S1P were increased compared with native HDL3-associated S1P (B). *P < 0.05 vs. healthy group. The levels of mRNA involved in S1P metabolism was measured by real-time PCR. C: The mRNA level of SPL and SGPP1/2 was detected in T2DM and control subjects. Mann–Whitney U test. Bars show medians. *p < 0.05.

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Cardiovascular Diabetology

ISSN: 1475-2840