Figure 1From: Atherogenic, fibrotic and glucose utilising actions of glucokinase activators on vascular endothelium and smooth muscleEffect of GKA on glucose concentration (A) and consumption (B) on rat MIN6 pancreatic beta cells. A. MIN6 cells treated with either 5 mM or 25 mM glucose medium conditions in the presence and absence of two glucokinase activators (RO28-1675 and Compound A) at 10 μM for 0–24 h. Direct D-glucose levels were measured in the medium for each treatment. Data presented from an experiment utilizing 3 wells/treatment. ##p < 0.01 = basal (24 h) versus basal (0 h) and ##p < 0.01 = treatment versus basal (24 h) determined using one-way-ANOVA on a per well basis. B. RO28-1675 and Compound A increased (p < 0.01) the rate of consumption of glucose by MIN6 cells treated with 5 mM and 25 mM glucose compared to basal levels of glucose consumption after 24 h. Results are **p < 0.01treatment versus basal, determined using one-way-ANOVA.Back to article page