TY - JOUR AU - Hou, Xuwei AU - Hu, Zhaohui AU - Xu, Hanying AU - Xu, Jian AU - Zhang, Shunrong AU - Zhong, Yigang AU - He, Xiuying AU - Wang, Ningfu PY - 2014 DA - 2014/04/14 TI - Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway JO - Cardiovascular Diabetology SP - 78 VL - 13 IS - 1 AB - Rat neonate cardiomyocytes were cultured and treated with AGEs at different concentration. Two classic autophagy markers, microtubule-associated protein 1 light chain 3 (LC3) and Beclin-1, were detected by western blot assay. The inhibition of RAGE and phosphatidylinositol 3-phosphate kinase (PI3K)/Akt/mTOR pathway were applied to cells, respectively. SN - 1475-2840 UR - https://doi.org/10.1186/1475-2840-13-78 DO - 10.1186/1475-2840-13-78 ID - Hou2014 ER -