Figure 1

Daily injections of OCN improve glucose tolerance and lipid metabolism in ApoE-KO mice. Analyses were performed in mice injected daily with the indicated doses of OCN or with vehicle for the indicated time. During 12 weeks of experimental intervention, body weight (A), FBG (B) was measured. After 12 weeks of experimental intervention, measurements were taken of serum lipid levels (C-F), glucose during GTT (G-H), insulin during GTT (I-J), and glucose by ITT (K-L). Values represent mean ± SEM, 6 to 8 mice per group were analyzed. *P < 0.05, **P < 0.01, OCN-treated mice vs. vehicle-treated mice in chow diet group; ^#P < 0.05, ^##P < 0.01, OCN-treated mice vs. vehicle-treated mice in HFD group. HF, high fat diet; CD, chow diet; OCN, osteocalcin; FBG, fasting blood glucose.