Skip to main content

Table 2 Basal characteristics and functional parameters of human cardiac muscle

From: Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction

Muscle characteristics Non-DM (n = 8) DM (n = 6) P value
CSA (mm2) 0.046 ± 0.036 0.051 ± 0.043 0.84
Lmax (mm) 1.73 ± 0.58 1.34 ± 0.15 0.18
Contractile parameters
Fdev (mN/mm2) 23.7 ± 3.6 23.1 ± 1.1 0.91
+dF/dtmax (mN/mm2/s) 298 ± 37 277 ± 21 0.70
TtPF (ms) 145 ± 16 139 ± 7 0.77
Relaxation parameters
-dF/dtmin (mN/mm2/s) -204 ± 20 -130 ± 16 0.02*
RT50% (ms) 166 ± 9 209 ± 6 0.01*
Tau (ms) 74 ± 4 93 ± 7 0.03*
  1. CSA - cross sectional area; Lmax- muscle length at maximal force development; Fdev - developed force; +dF/dtmax - maximum rate of contraction; TtPF - time to peak force; - dF/dtmin - minimum rate of relaxation; RT50% - 50% relaxation time; Tau - time constant of relaxation. Data are mean ± SEM; * = p < 0.05 vs. non-diabetic, unpaired t-test.