Skip to main content

Table 2 Basal characteristics and functional parameters of human cardiac muscle

From: Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction

Muscle characteristics

Non-DM (n = 8)

DM (n = 6)

P value

CSA (mm2)

0.046 ± 0.036

0.051 ± 0.043

0.84

Lmax (mm)

1.73 ± 0.58

1.34 ± 0.15

0.18

Contractile parameters

Fdev (mN/mm2)

23.7 ± 3.6

23.1 ± 1.1

0.91

+dF/dtmax (mN/mm2/s)

298 ± 37

277 ± 21

0.70

TtPF (ms)

145 ± 16

139 ± 7

0.77

Relaxation parameters

-dF/dtmin (mN/mm2/s)

-204 ± 20

-130 ± 16

0.02*

RT50% (ms)

166 ± 9

209 ± 6

0.01*

Tau (ms)

74 ± 4

93 ± 7

0.03*

  1. CSA - cross sectional area; Lmax- muscle length at maximal force development; Fdev - developed force; +dF/dtmax - maximum rate of contraction; TtPF - time to peak force; - dF/dtmin - minimum rate of relaxation; RT50% - 50% relaxation time; Tau - time constant of relaxation. Data are mean ± SEM; * = p < 0.05 vs. non-diabetic, unpaired t-test.