Figure 7
Hypothetical mechanism of the exenatide induced vasodilation according to our data and according to previous examinations [[3]-[7],[10]-[14],[19]-[31]]. HO: heme oxygenase, eNOS endothelial nitric oxide synthase, CSE: cystathionine-γ-lyase, COX: cyclooxygenase, PG: prostaglandin, H2S: hydrogen sulphide NO: nitric oxide, CO: carbon monoxide, O2–•:superoxide anion, PKA: cAMP-dependent protein kinase, PKG: cGMP-dependent protein kinase, BKCa: large-conductance calcium activated potassium channel, KCNQ: a type of voltage-gated potassium channel, KATP: ATP-sensitive potassium channel.