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Figure 6 | Cardiovascular Diabetology

Figure 6

From: Exenatide induces aortic vasodilation increasing hydrogen sulphide, carbon monoxide and nitric oxide production

Figure 6

Role of potassium channels and the Na+/Ca2+-exchanger in the vasodilator effect of exenatide. Blockade of large-conductance calcium-activated potassium channels with 2 mM tetraethylammonium (TEA) (A). Inhibition of ATP-sensitive potassium channels with 10 μM glibenclamide (B). KCNQ-type Kv channels blocked by 30 μM XE991 (C). Selective inhibition of the Na+/Ca2+-exchanger with 4 μM SEA0400 (D). 23.9, 71.7, 310, 788, 1980, 3170 nanomoles of exenatide were used to relax the vessels (n = 5 of each experiment), *P < 0.01 compared to the relaxation caused by exenatide only (at respective concentration of exenatide).

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