Skip to main content
Figure 5 | Cardiovascular Diabetology

Figure 5

From: Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1

Figure 5

Restoration of Pim-1 levels reverted female disadvantage. A bar graphs showing the levels of activated caspase-3/7. B-C representative blots and bar graphs showing the levels of Pim-1 (B) and Bcl-2 (C) in the isolated and cultured cardiomyocytes over expressed with either Pim-1 plasmid or scrambled plasmid. D representative blots and bar graphs showing the levels of Pim-1 in the isolated and cultured cardiomyocytes treated with either anti-miR-1/208a or scrambled sequence. E bar graphs showing the levels of activated caspase-3/7. Values are means ± SD. Results of pair-wise comparison are illustrated. **P < 0.01 and ***P < 0.001 vs. non-diabetic of corresponding gender. #P < 0.05 and ##P < 0.01 vs. male diabetic. $P < 0.05, $$P < 0.01 and $$$P < 0.001 vs. scrambled plasmid/sequence treated group of corresponding gender. All the experiments were run in triplicate and repeated 5 independent times.

Back to article page