Parameters | T2DM (n = 276) | Controls (n = 115) | P value | Elevated hs-TnI (n = 70) | Normal hs-TnI (n = 206) | P value |
---|---|---|---|---|---|---|
Age, years | 64.4 ± 10.0 | 63.4 ± 7.9 | 0.29 | 68.6 ± 9.2 | 62.9 ± 9.9 | <0.01 |
Male, % (n) | 154 (56) | 53 (61) | 0.35 | 70 (49) | 30 (21) | <0.01 |
Body mass index, kg/m2 | 25.5 ± 3.5 | 23.6 ± 3.4 | <0.01 | 25.4 ± 3.5 | 25.6 ± 3.6 | 0.72 |
Current smoker, % (n) | 33 (92) | 6 (7) | <0.01 | 49 (34) | 28 (58) | <0.01 |
Hypertension, % (n) | 70 (194) | 15 (17) | <0.01 | 89 (62) | 132 (64) | <0.01 |
Hypercholesterolemia, % (n) | 63 (174) | 30 (26) | <0.01 | 70 (49) | 61 (125) | 0.10 |
Duration of DM, years | 9.8 ± 7.6 | -- | -- | 10.2 ± 8.7 | 9.7 ± 7.3 | 0.67 |
CAD, % (n) | 29 (113) | -- | -- | 60 (42) | 35 (71) | <0.01 |
Total cholesterol, mmol/L | 4.6 ± 1.0 | 5.0 ± 0.9 | <0.01 | 4.5 ± 1.1 | 4.7 ± 1.0 | 0.15 |
Triglycerides, mmol/L | 1.6 ± 1.8 | 1.3 ± 0.8 | <0.01 | 1.6 ± 1.1 | 1.6 ± 1.9 | 0.99 |
High density lipoprotein, mmol/L | 1.3 ± 0.8 | 1.5 ± 0.4 | <0.01 | 1.2 ± 0.4 | 1.3 ± 0.4 | 0.16 |
Low density lipoprotein, mmol/L | 2.7 ± 0.8 | 3.0 ± 0.7 | <0.01 | 2.6 ± 0.8 | 2.7 ± 0.8 | 0.55 |
eGFR, mL/min per 1.73 m2 | 81.8 ± 19.3 | 85.8 ± 14.1 | 0.03 | 72.0 ± 18.7 | 84.2 ± 18.7 | <0.01 |
Fasting glucose, mmol/L | 7.6 ± 2.3 | 5.1 ± 0.5 | <0.01 | 7.6 ± 2.8 | 7.6 ± 2.1 | 0.96 |
HbA1c, % | 7.8 ± 1.4 | 5.9 ± 0.4 | <0.01 | 8.1 ± 1.7 | 7.7 ± 1.4 | 0.21 |
Medication | ||||||
Insulin, % (n) | 14 (38) | 0 (0) | <0.01 | 19 (13) | 12 (25) | 0.13 |
Aspirin, % (n) | 40 (109) | 0 (0) | <0.01 | 56 (39) | 34 (70) | <0.01 |
ACEI/ARB, % (n) | 60 (166) | 1 (1) | <0.01 | 77 (54) | 54 (112) | <0.01 |
Statin, % (n) | 42 (115) | 2 (2) | <0.01 | 57 (40) | 37 (75) | <0.01 |