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Figure 8 | Cardiovascular Diabetology

Figure 8

From: AGEs breaking and antioxidant treatment improves endothelium-dependent dilation without effect on flow-mediated remodeling of resistance arteries in old Zucker diabetic rats

Figure 8

Flow-mediated remodeling after treatment with TEMPOL: Changes in diameter (A,B) in response to stepwise increases in pressure in HF and NF mesenteric resistance arteries isolated from lean Zucker (LZ, A ) and diabetic fatty Zucker rats (ZDF, B) treated with TEMPOL. Concentration-response curves to acetylcholine were performed in NF (C) and HF (D) arteries in the presence or absence of L-NAME (100 μmol/L). Emax for acetylcholine-mediated relaxation (E) and the inhibitory effect of L-NAME on acetylcholine-mediated relaxation (F) were calculated from the curves shown in C and D. Mean ± SEM is presented (n = 10 per group). *P < 0.05, HF arteries compared to NF arteries. #P < 0.05, ZDF compared to LZ.

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Cardiovascular Diabetology

ISSN: 1475-2840