Experimental model: Schematic representation of the mesenteric circulation in rats and location of the ligations (arrows) of second-order mesenteric artery branches. The artery located between two ligated vessels was submitted chronically too high flow (HF) artery. Equivalent non-ligated arteries located at a distance from the ligatures had normal flow (NF). Rats were treated with ALT-711 plus TEMPOL (Alt + T) or not. The bargraph shows blood flow measurements obtained using a Transonic ® flow probe in HF and NF arteries of LZ and ZDF rats 14 days after ligation. Values are mean ± SEM (n = 4 to 6 per group). *P < 0.05, HF versus NF.