Figure 6
From: High glucose induces human endothelial dysfunction through an Axl-dependent mechanism
HG concentrations and Axl knockdown in HMEC-1Â s. The HMEC-1Â s were infected with Axl shRNA vectors and cultured in 5, 20 and 40Â mM glucose and equimolar concentrations of mannitol. The results revealed significant additive changes in the Akt phosphorylation, VCAM-1 expression (A), cell viability (B), tube formation (C) and monocyte-EC adhesion (D) of Axl-shRNA-infected HMEC-1 cells in HG culture compared with HG alone condition.