Figure 3
From: Impaired dopamine D1 receptor-mediated vasorelaxation of mesenteric arteries in obese Zucker rats
Effect of rosiglitazone on D 1 receptor expression and function in mesenteric arteries from obese Zucker rats. The mesenteric arteries from obese Zucker rats, treated with rosiglitazone (ROG) or vehicle, were incubated with varying concentrations of fenoldopam (10-9-10-5M). The vasorelaxation with fenoldopam is shown in 3A (*P < 0.05, vs. obese rats, n = 8 repeated measures ANOVA, Holm-Sidak test) while D1 receptor expression or phosphorylation in mesenteric arteries, determined by immunoblotting or co-immunoprecipitation, is shown in 3B and 3C, respectively. D1 receptor serine phosphorylation was normalized by D1 receptor protein. (*P < 0.05, vs. obese rats, n = 6),