Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial

Table 3 Association between the FAIM2 -rs7138803 polymorphism and categories of heart rate

	FAIM2(G > A) genotypes			Unadjusted¹		Adjusted²		Adjusted³
Heart rate	GG + GA (n = 6,049)		AA (n = 888)	OR* (95% CI)	P¹	OR* (95% CI)	P²	OR* (95% CI)	P³
<60 bpm (%)	90.1		9.9	1 (ref)		1 (ref)		1 (ref)
60-70 bmp (%)	87.3		12.7	1.32 (1.05-1.67)	0.019	1.27 (1.00-1.60)	0.051	1.26 (1.00-1.60)	0.052
70-80 bmp (%)	86.4		13.6	1.43 (1.13-1.82)	0.003	1.46 (1.14-1.87)	0.003	1.45 (1.13-1.86)	0.003
80-90 bmp (%)	86.1		13.9	1.46 (1.12-1.92)	0.006	1.47 (1.10-1.97)	0.009	1.46 (1.10-1.96)	0.011
> = 90 bmp (%)	85.0		15.0	1.60 (1.13-2.27)	0.008	1.65 (1.13-2.42)	0.010	1.66 (1.13-2.43)	0.009
P for trend*		0.002

Prevalence and odds ratios (OR). Unadjusted and adjusted models.
Values are prevalences in%, odds ratio (OR) and 95% confidence intervals (CI).
OR: Odds ratio for the corresponding category of heart rate in comparison with the reference category (<60 bpm) for homozygous subjects for the variant allele (recessive model) in comparison with carriers of the major allele.
*: P-value of the Chi² test for linear trend.
¹: Unadjusted P values for the polymorphism (recessive model).
²: Models adjusted for sex, age, center, type 2 diabetes, hypertension, physical activity, medications, smoking, drinking, adherence to Mediterranean diet and total energy intake.
³: Model 2 additionally adjusted for BMI.

ISSN: 1475-2840