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Table 2 Association between the FAIM2 -rs7138803 and anthropometrical measures, blood pressure and heart rate

From: Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial

 

FAIM2(G > A) genotypes

 

GG (n = 3,019)

GA (n = 3,235)

AA (n = 907)

Additive model

  

Recessive model

 

Mean

SD

Mean

SD

Mean

SD

P1

B1(95% CI)

P2

P3

B1(95% CI)

P1

P2

P3

Weight (kg)

76.4

± 11.9

76.9

± 11.9

77.3

± 12.1

0.026

0.46 (0.06-0.87)

0.059

 

0.59 (-0.24-1.42)

0.164

0.191

 

BMI (kg/m2)

29.9

± 3.8

30.0

± 3.9

30.1

± 3.9

0.055

0.13 (-0.01-0.26)

0.023

 

0.20 (-0.07-0.47)

0.147

0.066

 

Waist circumference (cm)

100.3

± 10.5

100.3

± 10.6

101.0

± 10.9

0.167

0.26 (-0.11-0.62)

0.141

 

0.68 (-0.07-1.42)

0.075

0.085

 

SBP (mmHg)

149.2

± 20.8

149.4

± 20.9

149.9

± 20.1

0.414

0.30 (-0.42-1.01)

0.783

0.889

0.57 (-0.89-2.03)

0.443

0.761

0.896

DBP (mmHg)

82.9

± 10.9

83.4

± 10.9

84.3

± 11.2

0.001

0.61 (0.24-1.00)

0.006

0.015

1.12 (0.36-1.89)

0.004

0.009

0.017

Heart rate (bpm)

71.1

± 11.2

71.2

± 10.9

72.3

± 11.4

0.029

0.43 (0.04-0.81)

0.039

0.048

1.07 (0.29-1.86)

0.007

0.010

0.012

Prevalence of obesity (%)

45.2

47.5

49.1

0.021

    

0.136

  

Obesity risk, OR (95% CI)

1 (ref.)

1.10 (0.99-1.21)

1.17 (1.01-1.35)

0.021

1.08 (1.01-1.16)

0.011

 

1.11 (0.97-1.28)

0.136

0.070

 
  1. Means, prevalence, odds ratios (OR), and regression coefficients (B).
  2. Values are means and standard deviations (SD), odds ratio (OR) and 95% confidence intervals (CI) or regression coefficients (B) and 95% CI.
  3. B: Regression coefficient per-variant allele effects in the additive model (genotypes coded as 0, 1 and 2 according to the number of minor alleles for additive effects) and regression coefficients for homozygotes for the variant allele versus the other genotypes in the recessive model (genotypes coded as 0 for GG and GA and 1 for AA).
  4. SBP: Systolic blood pressure. DBP: Diastolic blood pressure.
  5. 1: Unadjusted P values for the polymorphism for the comparison of means or OR (in an additive or recessive models as indicated).
  6. 2: Models adjusted for sex, age, center, type 2 diabetes, medications (antihypertensive drugs, lipid-lowering drugs and antidiabetic drugs) and diagnosed hypertension.
  7. 3: Model 2 additionally adjusted for BMI. Further adjustment for total energy intake, adherence to Mediterranean diet and physical activity did not change the statistical significance of these associations.
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Cardiovascular Diabetology

ISSN: 1475-2840