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Figure 1 | Cardiovascular Diabetology

Figure 1

From: Novel association of the obesity risk-allele near Fas Apoptotic Inhibitory Molecule 2 (FAIM2) gene with heart rate and study of its effects on myocardial infarction in diabetic participants of the PREDIMED trial

Figure 1

Longitudinal effect of the FAIM2 -rs7138803 polymorphism on heart rate in type 2 diabetic subjects. Adjusted means of heart rate in beats per minute (bpm) depending on the polymorphism (GG + GA versus AA) at baseline, 1, 3 and 5-years of follow-up in all type 2 diabetic subjects at baseline having data for all four measurements (n = 1,076). Adjusted means were estimated from a repeated-measures ANOVA model with interaction terms adjusted for dietary intervention (MedDiet versus control), sex, age, BMI, medications, smoking, and physical activity. Adjusted P values for the interaction term among the polymorphism, time, and dietary intervention as well for the overall effect of the polymorphism are shown. *Adjusted P values for the polymorphism at every specific time point. Further adjustment of the model for hypertension at baseline did not change the statistical significance of the results.

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Cardiovascular Diabetology

ISSN: 1475-2840