Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study

Table 2 Thresholds of FPG, 2-hour PG, HbA _1c , GA, and 1,5-AG levels for detecting diabetic retinopathy

	Threshold	Sensitivity	Specificity	PPV	NPV
	Threshold	(%)	(%)	(%)	(%)
FPG	6.5 mmol/l	82.7	86.6	10.9	99.6
2-hour PG	11.5 mmol/l	90.4	89.3	14.3	99.8
HbA_1c	6.1% (43 mmol/mol)	86.5	88.8	13.3	99.7
GA	17.0%	86.5	89.0	13.5	99.7
1,5-AG	12.1 μg/mL	78.8	85.8	9.9	99.5

FPG: fasting plasma glucose; 2-hour PG: 2-hour postload glucose; HbA_1c: hemoglobin A_1c; GA: glycated albumin; 1,5-AG: 1,5-anhydroglucitol; PPV: positive predictive value; NPV: negative predictive value.
The optimal threshold was defined as the point on the receiver operating characteristic curve closest to the ideal of 100% sensitivity and 100% specificity.

ISSN: 1475-2840