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Figure 4 | Cardiovascular Diabetology

Figure 4

From: Cardiovascular microRNAs: as modulators and diagnostic biomarkers of diabetic heart disease

Figure 4

Supporting the hypothesis that miRs could be a potential diagnostic biomarker for early diagnosis of diabetic heart disease. Heart disease in diabetes develops at a much earlier stage before it is clinically diagnosed and if undiagnosed and untreated, it may lead to HF at later stage. Diabetes is associated with marked molecular changes in the heart produced by miRs. These molecular changes occur before any structural and functional alteration in diabetic heart. Altered expression of miRs in diabetic heart inhibits the synthesis of essential proteins required for the normal cardiac physiology. Parallel to this, these cardiovascular miRs are also released into the bloodstream, where they can be easily detected as biomarkers for DHD.

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