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Table 2 Effects of vildagliptin on LV hemodynamic and echocardiographic data

From: Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats

 

Vehicle

ISO

ISO-VL

Cardiac catheterization

   

Number of rats

10

10

10

Heart rate (bpm)

404 ± 8

519 ± 7*

491 ± 8* #

LVSP (mmHg)

108 ± 3

113 ± 2

116 ± 2

LVEDP (mmHg)

2.2 ± 1.1

3.4 ± 0.9*

2.5 ± 1.0#

Maximum dp/dt (mmHg/s)

8992 ± 434

16,969 ± 592*

16,189 ± 713*

Minimum dp/dt (mmHg/s)

-8251 ± 531

-9936 ± 459*

-10080 ± 236*

Echocardiography

   

Number of rats

10

10

10

LVDd (mm)

6.78 ± 0.14

6.71 ± 0.04

6.74 ± 0.08

LVDs (mm)

3.62 ± 0.14

3.29 ± 0.08

3.41 ± 0.07

FS (%)

46.7 ± 2.7

51.0 ± 1.1

50.0 ± 0.9

IVST (mm)

1.34 ± 0.04

1.57 ± 0.23*

1.51 ± 0.03*

PWT (mm)

1.38 ± 0.04

1.62 ± 0.03*

1.56 ± 0.03*

E/A

1.61 ± 0.24

1.57 ± 0.07

1.53 ± 0.05

LVM (mg)

567 ± 16

695 ± 9*

663 ± 11* #

LVMI (mg/g)

2.36 ± 0.06

2.96 ± 0.04*

2.83 ± 0.04* #

  1. ISO, isoproterenol; VL, vildagliptin; LVSP, left ventricular systolic pressure; LVEDP, left ventricular end diastolic pressure; LVDd, left ventricular end-diastolic diameter; LVDs, left ventricular end-systolic diameter; FS, fractional shortening; IVST, interventricular septal thickness; PWT, posterior wall thickness; E, early transmitral peak diastolic flow velocity; A, late transmitral peak diastolic flow velocity; LVM, left ventricular mass; LVMI, left ventricular mass index. Values represent the mean ± SE. *p < 0.05 vs. vehicle; #p < 0.05 vs. ISO.
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Cardiovascular Diabetology

ISSN: 1475-2840