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Figure 5 | Cardiovascular Diabetology

Figure 5

From: Vaspin inhibits cytokine-induced nuclear factor-kappa B activation and adhesion molecule expression via AMP-activated protein kinase activation in vascular endothelial cells

Figure 5

AMPK activation mediates the inhibitory effects of vaspin on TNFα-induced NF-κB activation and expression of adhesion molecules. The effects of vaspin on TNFα-induced NF-κB promoter activity (A) and mRNA expression of the adhesion molecules ICAM-1 (B), VCAM-1 (C), E-selectin (D), and MCP-1 (E) were measured at 24 hr after treatment of HAECs with 100 ng/mL vaspin in the presence of absence of 10 ng/mL TNFα. HAECs were transfected with control siRNA or AMPKα1 siRNA 24 hr before. Data shown are mean values ± SEM of five independent experiments. *p < 0.05 vs. untreated cells, †p < 0.05 vs. cells treated with vaspin alone, and §p < 0.05 vs. cells treated with TNFα alone.

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Cardiovascular Diabetology

ISSN: 1475-2840