Figure 4

Effect of chronic cotreatment with AngIV or PD123319 in 6 weeks diabetic mice on endothelial function. (A) Mice were treated for two weeks after 4 weeks of diabetes initiation with vehicle (6 w diab), AngIV 1.4 mg/kg/day alone (6 w diab + AngIV), or combined with the specific AT4 antagonist Divalinal 2 mg/kg/d (6 w diab + AngIV + Div). # # # p < 0.001 for AngIV + Divalinal versus AngIV alone. (B) Mice were treated for two weeks after 4 weeks of diabetes initiation with the specific AT2 antagonist PD123319 20 mg/kg/d (6 w diab + PD) alone or in combination with AngIV (6 w diab + AngIV + PD). #versus (diab).