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Table 2 Changes in body composition and metabolic parameters following 12-week liraglutide treatment

From: Changes in liraglutide-induced body composition are related to modifications in plasma cardiac natriuretic peptides levels in obese type 2 diabetic patients

Variable

Pre-treatment (n = 31)

Post-treatment (n = 31)

Mean changes from baseline (95% CI)

p value

Weight (kg)

91.6 ± 12.4

86.5 ± 12.5

-5.03 (-5.81, -3.80)

<0.001

BMI (kg/m2)

31.7 ± 3.6

29.9 ± 3.8

-1.74 (-2.02, -1.31)

<0.001

waist circumference (cm)

108.7 ± 8.8

105.7 ± 9.2

-3.00 (-3.89, -2.11)

<0.001

Total fat mass (kg)

33.77 ± 10.33

29.98 ±10.76

-3.79 (-4.53, -3.05)

<0.001

Total lean mass (kg)

54.88 ± 8.42

53.36 ± 8.34

-1.52 (-2.03, -1.10)

<0.001

Relative total body Fat (%)

37.89 ± 8.22

35.60 ± 9.01

-2.29 (-2.91, -1.66)

<0.001

Relative total body Lean (%)

62.06 ± 8.22

64.39 ± 9.01

2.34 (1.67, 3.01)

<0.001

Abdominal VAT areas (cm2)

277.80 ± 68.75

235.49 ± 65.62

-42.31 (-50.28, -34.33)

<0.001

Abdominal SAT areas (cm2)

212.65 ± 83.17

189.35 ± 83.37

-23.29 (-29.43, -17.16)

<0.001

VAT:SAT ratio

1.41 ± 0.62

1.34 ± 0.64

-0.06 (-0.11, -0.02)

0.009

HbA1c (%)

8.19 ± 0.77

7.13 ± 0.54

-1.06 (-1.25, -0.87)

<0.001

FBG (mmol/L)

8.63 ± 1.20

6.86 ± 0.73

-1.77 (-2.16, -1.39)

<0.001

P2BG (mmol/L)

13.05 ± 2.72

8.66 ± 0.91

-4.39 (-5.24, -3.54)

<0.001

sFCP (ng/mL)

2.23 ±1.17

3.51 ±1.80

1.27 (0.73, 1.81)

0.001

CPI

1.47 ±1.01

2.74 ±1.47

1.27 (0.58, 1.97)

<0.001

HOMA-IR

9.15 ± 4.63

6.55 ± 2.93

-2.60 (-3.96, -1.25)

0.001

SBP (mmHg)

138.2 ± 11.2

132.9 ± 12.3

-5.3 (-7.9, -2.6)

<0.001

DBP (mmHg)

85.9 ± 6.4

83.4 ± 8.0

-2.5 (-4.2, -0.8)

0.005

TG (mmol/L)

2.89 ± 1.74

1.67 ± 0.60

-1.22 (-1.87, -0.57)

0.001

TC (mmol/L)

5.14 ± 1.17

4.40 ± 0.97

-0.75 (-1.27, -0.23)

0.007

LDL-C (mmol/L)

2.90 ± 0.87

2.79 ± 0.78

-0.11 (-0.45, -0.23)

0.511

HDL-C (mmol/L)

1.26 ± 0.23

1.36 ± 0.22

0.10 (0.03, 0.16)

0.006

  1. Normally distributed data expressed as mean ± standard deviation and non-normally distributed data expressed as median or as numbers and percentages. Non-normally distributed data were log-transformed for use with parametric statistics. BMI: body mass index. Relative total body Fat: fat percentage of total body weight. Relative total body Lean: lean percentage of total body weight. SAT: subcutaneous adipose tissue. VAT: visceral adipose tissue. HbA1c: glycosylated haemoglobin A1c. FBG: fasting blood glucose. P2BG: 2-hour postprandial blood glucose. sFCP: serum fasting C-peptide. CPI: C-peptide index. HOMA-IR: homeostasis model assessment of insulin resistance. CPI = sFCP (ng/mL) × 100/fasting glucose (mg/dL). HOMA-IR = fasting glucose (mg/dL) × fasting insulin (μU/ml)/405. 95% CI: lower 95% confidence interval limit, upper 95% confidence interval limit. SBP: systolic blood pressure. DBP: diastolic blood pressure. TG: triglyceride. TC: total cholesterol. LDL-C: low density lipoprotein-cholesterol. HDL-C: high density lipoprotein-cholesterol.