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Figure 2 | Cardiovascular Diabetology

Figure 2

From: The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK- and MAPK-dependent mechanisms

Figure 2

Atherosclerotic lesion formation in aortic sections from ApoE-/- mice. Sitagliptin reduced atherosclerotic lesion formation in ApoE-/- mice. (A) Aortic en face flat from the aortic root to the renal artery stained with Sudan IV. (B) En face flat of the aortic arch. (C) Aortic en face flat of the abdominal aorta. (D) Relative atherosclerotic lesion area of the atherosclerotic lesion to the whole aorta in the two groups. (E) Relative atherosclerotic lesion area in the aortic arch. (F) Relative atherosclerotic lesion area in the abdominal aorta. Data are mean ± SD, n = 6. *p < 0.05, **p < 0.01 versus control.

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