Skip to main content
Figure 4 | Cardiovascular Diabetology

Figure 4

From: Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser1177/Thr497 of endothelial nitric oxide synthase in diabetic mice

Figure 4

Gene expression in aorta (upper panel), perivascular fat (middle panel), and soleus muscle (lower panel). Samples isolated from male KKAy mice fed standard moderate-fat (MF) diet (black bars) and MF diet mixed with 0.005% candesartan cilexetil (gray bars) or 0.005% azilsartan (shaded bars) for 3 weeks since 8–10 weeks of age, were analyzed by semiquantitative RT-PCR. Gapdh was used as an internal control. Values shown represent mean ± SEM (n = 4–6).†p < 0.05 compared to C57BL/6 J and +p < 0.1 and *p < 0.05 compared to KKAy-vehicle according to either the Kruskal–Wallis test or unpaired t test. TNFα: tumor necrosis factor α; MCP1: monocyte chemotactic protein 1; PPARγ: peroxisome proliferator–activated receptor γ2; IRS-1: insulin receptor substrate 1; and Adipo: adiponectin.

Back to article page