Figure 1From: Azilsartan, an angiotensin II type 1 receptor blocker, restores endothelial function by reducing vascular inflammation and by increasing the phosphorylation ratio Ser1177/Thr497 of endothelial nitric oxide synthase in diabetic miceGlucose tolerance test (GTT) and insulin tolerance test (ITT). GTT and ITT were performed in male KKAy mice fed standard moderate fat (MF) diet (KKAy-Vehicle, ○) and MF mixed with 0.005% candesartan cilexetil (KKAy-Candesartan groups, □) or 0.005% azilsartan (KKAy-Azilsartan, ●) for 2 weeks since 8–9 weeks of age. Age-matched C57BL/6 J male mice were used as a control group (△). The data are shown as mean ± SEM.Back to article page