Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK

Table 3 ECG parameters in gck ^w/– and gck ^w/w mice (n = 6)

	gck^w/w	gck^w/–	gck^w/– + Ins	gck^w/– + RSG
Heart Rate(BPM)	613.9 ± 51.47	537.9 ± 65.6	592.6 ± 87.3	505.3 ± 39.9
P Duration(ms)	9.22 ± 1.64	14.82 ± 7.68	8.06 ± 1.96	10.82 ± 1.36
PR Interval(ms)	38.28 ± 2.31^*	44.77 ± 7.46^#	36.75 ± 6.29^*	38.41 ± 0.67^*
QRS Interval(ms)	8.54 ± 1.35^**	13.35 ± 3.28^##	8.37 ± 1.87^*	9.77 ± 0.71^*
QT Interval(ms)	18.06 ± 1.56	21.04 ± 2.28	16.98 ± 0.60	16.13 ± 1.89
QTc(ms)	58.10 ± 3.83	63.28 ± 10.73	53.36 ± 5.81	46.92 ± 6.97

Data are expressed as the mean ± standard. QTc, Corrected QT Interval. QTc = QT/(RR/100)1/2. n = 3 for all samples. Asterisk (*) refers to statistical significance (P < 0.05 for * and P < 0.005 for **) in comparisons with gck^w/– mice, while # refers to statistical significance (P < 0.05 for # and P < 0.005 for ##) in comparisons with gck^w/w mice.

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