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Table 2 Echocardiographic measurements (M-mode) in gck w/– and gck w/w mice (n = 3)

From: Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK

 

gckw/w

gckw/–

gckw/– + Ins

gckw/– + RSG

LVID;d

2.55 ± 0.15*

2.06 ± 0.16#

2.54 ± 0.15*

2.50 ± 0.12*

LVPW;d

0.84 ± 0.10*

1.03 ± 0.06#

1.27 ± 0.10#*

1.08 ± 0.07#

LVID;s

1.15 ± 0.05*

0.84 ± 0.08#

0.86 ± 0.07*

0.89 ± 0.11*

LVPW;s

1.14 ± 0.14*

1.54 ± 0.17#

1.90 ± 0.09#*

1.74 ± 0.03#*

LVAW;d

0.93 ± 0.09

0.83 ± 0.21

1.19 ± 0.09#*

0.94 ± 0.06

LVAW;s

1.12 ± 0.42

1.48 ± 0.15

1.76 ± 0.05*

1.48 ± 0.39

%EF

86.87 ± 1.97

90.62 ± 2.31

94.08 ± 1.23*

93.23 ± 2.07*

%FS

54.49 ± 2.58

59.31 ± 3.52

66.19 ± 2.59#*

64.61 ± 4.01#*

  1. Data are expressed as the mean ± standard. LVID;d, LV internal diameter in diastole. LVPW;d, LV posterior wall thickness in diastole. LVID;s, LV internal diameter in systole. LVPW;s, LV posterior wall thickness in systole. LVAW;d, LV anterior wall thickness in diastole. LVAW;s, LV anterior wall thickness in systole. EF, Ejection fraction. FS, Fractional shortening. n = 3 for all samples. Asterisk (*) refers to statistical significance (P < 0.05 for *) in comparisons with gckw/– mice, while # refers to statistical significance (P < 0.05 for #) in comparisons with gckw/w mice.