Figure 7
Changes in the protein levels of Insulin signaling pathway in hearts of 60-week old liver-specific gck knockout mice. Representative Western blots images (A) with quantification of IR (B), PI3K (C), Akt (D), and mTOR (E) from heart homogenates of wild-type (gckw/w) and gck knockout (gckw/–) mice as well as knockout mice treated with insulin or rosiglitazone for 4 weeks are shown. n = 3 for all samples. Asterisk (*) refers to statistical significance (P < 0.05 for * and P < 0.001 for ***) in comparisons with gckw/– mice, while # refers to statistical significance (P < 0.05 for # and P < 0.001 for ###) in comparisons with gckw/w mice.