Figure 6
Changes in mitochondrial ultrastructure in the hearts of 60-week old liver-specific gck knockout mice. Representative electron micrographs (×12,000 or × 60,000) (A), stereological quantification of mitochondrial volume density (B), and mitochondrial number (C) of wild-type (gckw/w) and gck knockout (gckw/–) mice as well as knockout mice treated with insulin or rosiglitazone for 4 weeks are shown. Cristae density (white arrow) was decreased in the gckw/–mice. Asterisk (*) refers to statistical significance (P < 0.05) in comparisons with gckw/– mice, while # refers to comparisons with gckw/w mice.