Figure 2From: Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPKIntra-peritoneal glucose tolerance tests (ipGTT) in 60-week old liver-specific gck knockout mice. ipGTT (A) and areas under the curve of the ipGTT (AUC) (B) are shown. Glucose levels were measured at 0, 30, 60, 120 minutes after glucose injection in wild-type (gckw/w) and gck knockout (gckw/–) mice as well as knockout mice treated with insulin or rosiglitazone for 4 weeks. n = 6 for all samples. Asterisk (*) refers to statistical significance (P < 0.05) in comparisons with gckw/– mice, while # refers to comparisons with gckw/w mice.Back to article page