Figure 6
From: An accelerated mouse model for atherosclerosis and adipose tissue inflammation
A sucrose-rich high-fat diet accelerates atherosclerotic plaque formation. LDLR-/- mice were fed HFSC, HFC or LF and ApoE-/- mice were fed HFSC. Atherosclerotic lesion formation was quantified using en-face analysis after dietary treatment for 16 weeks (A; n = 5 animals per group) or 20 weeks (B; n = 6 animals per group). C: Representative image of Sudan IV-stained aorta of indicated group after dietary treamtent for 16 weeks. For statistical analysis LDLR-/- mice fed HFSC or LF were compared with HFC-fed LDLR-/- mice. In addititon, LDLR-/- and ApoE-/- mice both fed HFSC were compared. All data represent mean ± SEM. *P < 0.05, ***P < 0.001.