Figure 5
From: An accelerated mouse model for atherosclerosis and adipose tissue inflammation
Sucrose-enriched high fat diet partly accelerates hepatic inflammation. LDLR-/- mice were fed either HFSC, HFC or LF for 16 or 20 weeks (n = 6 animals per group). ApoE-/- mice were fed HFSC for 16 weeks (n = 8 animals per group). Hepatic lipogenic gene expression of FAS (Fas) (A), ACC (Acaca) (B), SCD-1 (Scd1) (C) and hepatic expression of the inflammatory genes for macrophage marker F4/80 (encoded by Emr1) (D), MCP-1 (Ccl2) (E), TNFα (Tnf) (F), and osteopontin (OPN; Spp1) (G) were analyzed by real-time RT-PCR. For statistical analysis LDLR-/- mice fed HFSC or LF were compared with HFC-fed LDLR-/- mice. In addititon, LDLR-/- and ApoE-/- mice both fed HFSC were compared. All data represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.