Do incretins improve endothelial function?

Table 2 Clinical evaluation of endothelial function

Author	Subjects	n	Endothelial function	Medication	Control	Duration	Result
Basu A et al.[41]	T2DM	29	Strain-gauged plethysmography	GLP-1	Placebo	240 min	Improved
Kubota Y et al.[42]	T2DM	40	FMD	Sitagliptin	None	12 w	Improved
Nystrom T et al.[43]	T2DM	12	FMD	GLP-1	Saline	115 min	Improved
Koska J et al.[44]	T2DM	28	PAT	Exendin-4	Saline	210 min	Improved
Noda Y et al.[45]	Healty volunteer	10	FMD	Alogliptin	Placebo	1 w	Improved
van Poppel PC et al.[46]	T2DM	16	Strain-gauged plethysmography	Vildagliptin	Acarbose	4 w	Improved
Ceriello A et al.[47]	T2DM	28	FMD	GLP-1	Saline	2 h	Improved
Irace C et al.[48]	T2DM	20	FMD	Exendin-4	Glimepiride	16w	Improved
Tesauro M et al.[37]	Metabolic syndrome	10 (5/5)	Strain-gauged plethysmography	GLP-1	Saline	30 min	Improved (conditional)
Kelly AS et al.[38]	IGT	50	PAT	Exendin-4	Metformin	6 m	No change
Hopkins ND, et al.[39]	Obese T2DM	11	FMD	Exendin-4 (n = 9) Liragrutide (n = 2)	None	6 m	No change
Ayaori M et al.[40]	T2DM	13 ~ 20,22	FMD	Sitagliptin/alogliptin	Voglibose	6 w	Worsened

T2DM: type2 diabetes mellitus, GLP-1: glucagon-like peptide-1, FMD: flow-mediated dilation, IGT: impaired glucose tolerance, PAT: Peripheral arterial tonometry.

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