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Table 1 Features of incretin-related therapy

From: Do incretins improve endothelial function?

 

Administration

Clearance

Side effects

GLP-1R agonist

Subctaneous

 

Weight loss

Gastrointestinal tract (GIT)

Exenatide

Twice a day, once a week

Renal

+

++/±*

Liraglutide

Once a day

Extrarenal

+

+

DPP-4 inhibitor

Oral

 

→

→

Sitagliptin

Once a day

Renal

→

→

Vildagliptin

Twice a day

Renal

→

→

Saxagliptin

Once a day

Renal

→

→

Linagliptin

Once a day

Extrarenal

→

→

Anagliptin

Twice a day

Renal

→

→

Teneligliptin

Once a day

Extrarenal > renal

→

→

Alogliptin

Once a day

Renal

→

→

  1. *Exenatide once weekly has less side effects of GIT as compared to linagrutide.