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Table 2 Parameters of micro- and macrocirculation (n = 42)

From: Effects of saxagliptin on early microvascular changes in patients with type 2 diabetes

 

Placebo

Saxagliptin

p-value

Retinal capillary flow

   

  RCF basal (AU)

314 ± 14.1

288 ± 13.2

0.033

  RCF flicker (AU)

331 ± 13.6

323 ± 16.8

0.462

  ∆ (AU)

16.6 ± 7.9

32.8 ± 8.7

0.195

  ∆ (%)

6.6 ± 2.2

11.4 ± 2.5

0.176

  RCF pre L-NMMA (AU)

318 ± 11.3

306 ± 13.5

0.245

  RCF post L-NMMA (AU)

318 ± 12.8

297 ± 13.1

0.116

  ∆ (AU)

0.0 ± 6.9

- 9.0 ± 7.5

0.442

  ∆ (%)

0.0 ± 2.1

- 2.1 ± 2.2

0.553

Retinal arteriolar structure

   

  WLR (-)

0.38 ± 0.01

0.39 ± 0.1

0.727

  WT (μm)

14.8 ± 0.5

14.8 ± 0.6

0.987

  Vessel diameter (μm)

107.7 ± 1.7

106.7 ± 2.0

0.394

  Lumen diameter (μm)

78.1 ± 1.2

77.0 ± 1.4

0.256

Macrocirculation

   

  Central SBP (mmHg)

124 ± 2.3

119 ± 2.3

0.038

  Central PP (mmHg)

45.3 ± 2.0

41.9 ± 2.0

0.058

  Central AP (mmHg)

12.4 ± 0.9

11.0 ± 1.0

0.094

  cAIx@75 (%)

23.0 ± 1.2

21.8 ± 1.3

0.212

  PWV (m/s)

8.86 ± 0.26

8.56 ± 0.26

0.260

  UACR (mg/g creatinine)

5.0 (4.0 – 12.5)

6.0 (4.0 – 9.0)

0.285

  1. Legend: RCF, retinal capillary flow; AU, arbitrary unit; L-NMMA, NG-monomethyl-L-arginine; WLR, wall to lumen ratio; WT, wall thickness; SBP, systolic blood pressure; PP, pulse pressure; AP, augmentation pressure; cAlx@75, central augmentation index normalized to a heart rate of 75 beats/min; PWV, pulse wave velocity; UACR, urinary albumin-creatinine ratio.